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As the rising phase reaches its peak, voltage-gated Na channels are inactivated whereas voltage-gated K channels are activated, resulting in a net outward movement of K ions, which repolarizes the membrane potential towards the resting membrane potential.Repolarization of the membrane potential continues, resulting in an undershoot phase or absolute refractory period.
Such a process is also known as a positive feedback loop.Moreover, the distinctions based on function between neurons and other cells such as cardiac and muscle cells are not helpful.Thus, the fundamental difference between a neuron and a nonneuronal cell is a matter of degree.Several techniques such as intracellular recording, patch-clamp, and voltage-clamp technique, pharmacology, confocal imaging, molecular biology, two photon laser scanning microscopy and Ca2 imaging have been used to study activity at the cellular level.Cellular neuroscience examines the various types of neurons, the functions of different neurons, the influence of neurons upon each other, how neurons work together.The undershoot phase occurs because unlike voltage-gated sodium channels, voltage-gated potassium channels inactivate much more slowly.
Nevertheless, as more voltage-gated K channels become inactivated, the membrane potential recovers to its normal resting steady state..
When there is a change in voltage in the terminal bouton, voltage-gated calcium channels embedded in the membranes of these boutons become activated.
These allow Ca2 ions to diffuse through these channels and bind with synaptic vesicles within the terminal boutons.
In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity.
Since memories are postulated to be represented by vastly interconnected networks of synapses in the brain, synaptic plasticity is one of the important neurochemical foundations of learning and memory (see Hebbian theory).
Neurons are cells that are specialized to receive, propagate, and transmit electrochemical impulses.